MonoMethyl auristatin E

Name	Monomethylauristatin E
Synonyms	MMAE Vedotin HM-297C-22 Monomethylauristatin E MonoMethyl auristatin E MonoMethyl auristatin E(MMAE, vedotin) (S)-N-((3R,4S,5S)-1-((S)-2-((1R,2R)-3-(((1R,2R)-1-Hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl)pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxohe N-Methyl-L-valyl-N-[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenylethyl]amino]-1-methoxy-2-methyl-3-oxopropyl]-1-pyrrolidinyl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-methyl-L-valinamide Monomethyl
CAS	474645-27-7

Molecular Formula	C39H67N5O7
Molar Mass	717.98
Density	1.088±0.06 g/cm3(Predicted)
Melting Point	>90°C (dec.)
Boling Point	873.5±65.0 °C(Predicted)
Solubility	DMSO: ≥ 48 mg/mL
Appearance	Solid
Color	White to Off-White
pKa	13.66±0.20(Predicted)
Storage Condition	-20°C Freezer
In vitro study	When coupled to cAC10, MMAE at CD30 in vitro, when coupled to anti-cd79b antibody, anti-CD79b-vcMMAE has very potent and broad activity against a large group of NHL cell lines. When coupled with an anti-HER2 antibody, hertuzumab-vc-MMAE can be fully taken up and effectively kill HER2 overexpressing tumor cells.
In vivo study	In The Karpas 299 ALCL model, cAC10-vcMMAE (1 mg/kg, I. v.) complete, long-lasting tumor regression was induced, whereas free MMAE (0.36 mg/kg) produced no detectable antitumor activity. In the NHL mouse xenograft model, anti-CD79b-vcMMAE (7 mg/kg, p.o.) significantly resulted in sustained complete tumor regression.

Last Update：2024-01-02 23:10:35

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QQ: 2853786052

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CAS: 474645-27-7
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MonoMethyl auristatin E

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